Metazome

Metazome is a database and graphical user interface enabling comparative genomic studies within the Metazoa. As of version 1.1, the database houses eleven sequenced animal genomes and is constantly growing as new genomes become available. Each gene has been annotated with PFAM, KOG, and PANTHER assignments, and publicly available annotations from RefSeq, SwissProt, Ensembl, and JGI are hyper-linked and searchable. For comparative studies, various clustering methods have been applied to construct orthologous groups of genes that represent the modern descendents of ancestral gene sets at key phylogenetic nodes, including the ancestral tetrapod and vertebrate. These clusterings allow easy access to clade specific orthology/paralogy relationships as well as clade specific genes and gene expansions. Position specific profiles will be made available shortly and gene phylogenetic trees are available now for each cluster to enable deeper comparative studies. The website is supported by the DOE Joint Genome Institute and the Center for Integrative Genomics at UC Berkeley.